Sandra appeared on many shows during the 1980s and 1990s, notably as a lesbian on Roseanne. She was also in The King of Comedy with Robert DeNiro and Hudson Hawk with Bruce Willis.
A film adaptation of her one-woman show titled Without You I'm Nothing (Netflix) is extremely funny, and she embraces the ambivalence the public feels for her. Each time the emcee introduces her he calls her "Sarah Bernhard" and the faux audience is typically shown as either bored or hostile towards her. In the end she sings Prince's "Little Red Corvette" and does a striptease. Before it is over you see that the crowd has left, save one woman who writes on the table before her in lipstick, "fuck Sandra Bernhard." It is an uncomfortable film. Not everything Bernhard says is funny, and many of the laughs are of the uncomfortable variety; that I feel is where the brilliance lay. She is very into art and high-fashion, both of which are supposed to shock, and often nothing is more shocking that pointing out the ridiculousness of one's self.
I'll close with a quote that I rather like, then some pictures.